What is the E50-H Exosome?
If you’ve been researching non-surgical hair loss treatments, you may have seen E50 come up by name. It is the specific product we use at Hair Revive, and patients often arrive at consultation already asking about it.
So let’s explain, without the jargon, what E50 actually is, where it comes from, how we use it for hair loss, what the research does and does not yet show, and how it sits within UK regulation.
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The full product name is E 50-H for Hair, made by PrimaCure Co., Ltd in South Korea
The exosomes inside it are sourced from salmon cells and supplied by STEMON Inc., a South Korean biotechnology company
It comes as a dual ampoule system: a dry ampoule containing the exosome powder, and a solvent ampoule used to reconstitute it just before use
It is an emerging treatment: early evidence is positive but it is not a licensed medicine, and the E 50-H specifically has not appeared in any peer-reviewed systematic review
What Is E50-H, in Plain English?
Your cells talk to each other all the time. One of the ways they do it is by releasing tiny parcels called exosomes.
Each exosome is a microscopic bubble, far too small to see, packed with growth factors, snippets of genetic instructions and other signalling molecules. When one cell releases an exosome and another cell receives it, the receiving cell reads the contents and may respond, by growing, repairing, or behaving differently.
Exosome therapy borrows this natural signalling system. Instead of making your cells produce the signals, a concentrated preparation of exosomes is applied directly to the area you want to influence. In our case, your scalp.
Who makes E 50-H, and what comes in the box
The full product name is E 50-H for Hair. You may also see the product referred to simply as "E50" in clinic communications. The formal product line is E 50-H for Hair; "E50" is the shorthand version commonly used in practice.
It is formulated and manufactured by PrimaCure Co., Ltd, a biotech company based in Incheon, South Korea.
PrimaCure specialises in exosome-based formulations and precision delivery systems for aesthetic and regenerative use.
The exosome ingredient itself comes from STEMON Inc., a separate South Korean biotechnology company, who supply salmon-derived exosomes as the active component within PrimaCure's formulation.
So when you see references to "E50 Exosome" in UK clinics, PrimaCure is the product you are getting, with STEMON's exosome technology inside it.
The dual ampoule system
E 50-H is not a single-vial liquid. It comes as a two-part system that is prepared at the point of care, immediately before use.
Dry ampoule
This contains a lyophilised (freeze-dried) powder holding the salmon-derived exosomes and sodium hyaluronate. Storing the exosomes in powdered form preserves their activity over the shelf life of the product.
Solvent ampoule
This contains a liquid solution of peptides and supportive actives. When the session is ready to begin, the solvent is combined with the dry powder to reconstitute the preparation.
Reconstitution just before use is the standard approach for sensitive biologicals. It means the product is at its most active when applied, rather than sitting in a degraded liquid state.
Why salmon?
The exosomes in E 50-H are collected from salmon testes cells. That may sound unusual, but it is a deliberate choice with practical reasoning behind it.
Using salmon-derived cells avoids the regulatory and safety questions that come with human-derived tissue, which UK cosmetics rules do not allow in this context. Salmon cells can be produced at scale under controlled conditions, with consistent quality batch after batch. Salmon-sourced ingredients are already established in the UK aesthetics market: polynucleotides derived from salmon, sometimes marketed as PDRN, are a well-known example.
What's Inside E50, and Why It Matters for Your Hair
The simplest way to think about E 50-H is as a delivery of biological messages aimed at your hair follicles. Those messages come in several forms.
Salmon-derived exosomes
These are the central active component. These are nanosized vesicles, the actual parcels, carrying growth factors, peptides and signalling molecules to the cells they interact with. PrimaCure states that the active components are supplied at a concentration of 50 billion per millilitre, which is where the "E50" name originates. This figure comes from the manufacturer and has not been independently verified.
Sodium hyaluronate
This a form of hyaluronic acid already well-established in clinical aesthetics. In E 50-H it supports the reconstituted preparations consistency and the scalp environment it is delivered into.
Growth factor complex
This refers to the proteins present in the exosome payload that signal cells to divide, repair and maintain a healthy local blood supply. Several of the growth factors involved in follicle biology, including VEGF, which supports small blood vessels feeding each follicle, are found within exosome preparations of this type.
Peptide blend
This is the active component of the solvent ampoule. Peptides are short chains of amino acids used as targeted signalling molecules in many clinical skincare and scalp formulations.
Delivery enhancers
These are included to support the preparation's ability to reach the follicle level during a clinical session.
Getting these "messages" down to the hair follicles in the dermal layer is the objective. The microneedling we use during every session is the step that makes that possible.
How Exosomes Help With Hair Loss
To understand why any of this matters, it helps to know what is actually going wrong in most pattern hair loss.
The short version of the biology
Each hair on your scalp cycles through three phases: an active growth phase (anagen), a short transition (catagen), and a rest phase (telogen) before the hair sheds and the cycle begins again. Anagen is where most of the visible length happens, and it typically lasts years on the scalp.
Anagen
"Growth Phase"
The Active Growth Phase typically lasts 2-7 Years on the Scalp
Catagen
"Transition Phase"
Short Transition Phase where Follicle Shrinks
Telogen
"Rest Phase"
Lasts around 3 months before the hair is shed and cycle repeats
In pattern hair loss, the most common type in both men and women, a hormone called DHT gradually shortens the anagen phase in genetically susceptible follicles. Each cycle, the hair comes back a little thinner and finer. Eventually, if nothing intervenes, the follicle miniaturises to the point where it stops producing hair altogether. Dermatologists call this process miniaturisation.
Where E 50-H fits in
The treatment target is to slow or counter that process: extend the growth phase, keep struggling follicles active, and support the cellular environment around them.
E 50-H's payload of growth factors and peptides is aimed at exactly that target. The growth factors support the blood vessels and cells around each follicle. The signalling molecules in the exosomes interact with the cellular programmes that control the shift between growth and rest phases. The preparation also provides a supportive local environment through sodium hyaluronate and the peptide blend.
Whether those theoretical effects translate into visible results depends on your specific pattern of loss, whether your follicles are still active and responsive, and the consistency of the treatment course. We are honest about the limits of what can be predicted in advance.
How We Use E 50-H at Hair Revive
We apply E 50-H to your scalp using microneedling. We do not inject it. That matters for the patient experience and for where we sit within UK regulation.
Inside a typical session
AI Scalp Scan
We assess the affected area at a microscopic level with our AI Scalp Scan.
Microneedle the Area
We pass a microneedle across the affected treatment area.
Apply E50-H Exosome
The E50-H Exosome Treatment is topically applied to the prepared area.
Apply TargetCool
TargetCool is applied to make the process more comfortable and support treatment.
A session starts with a cleansed scalp. A topical anaesthetic is available if you would prefer one, though many patients do not need it.
Next is a microneedling pass. Microneedling uses a device that creates fine, shallow channels in the skin. The channels are temporary, your skin closes them within hours, but while they are open they allow the E 50-H preparation to reach the follicle level rather than sitting on the surface.
The dry and solvent ampoules are then combined and the preparation applied to the prepared scalp. We then use the TargetCool device. TargetCool uses a controlled CO2 cooling mechanism to keep the session comfortable and supports transdermal delivery into the skin layers beneath the surface.
A session takes around forty-five minutes. There is no meaningful downtime, and most patients return to normal activity the same day.
What the Research Actually Shows
This is where honesty matters most. Published research specifically on E 50-H, or on salmon-derived exosomes for hair loss, is limited. We would rather state that directly than stretch what the evidence supports.
The broader exosome picture
Exosomes as a category for hair loss have been studied in a growing number of small clinical trials. A 2025 systematic review in Clinical, Cosmetic and Investigational Dermatology pulled together eleven of them, including two randomised controlled trials. Every study showed improvements in hair density or thickness, and no serious side effects were reported. An earlier 2024 study in Aesthetic Plastic Surgery followed thirty men with pattern hair loss and reported density gains at one and three months.
Te research above used exosomes from human or mammalian stem cells, not salmon. E 50-H is a different source material, so the broader literature provides context but is not direct evidence for the E 50-H preparation specifically. The E 50-H has not been the subject of a peer-reviewed clinical study or systematic review at the time of writing.
What PrimaCure says about their product
PrimaCure describes the E 50-H as designed to support scalp revitalisation through targeted exosome delivery. They state active components are present at 50 billion per millilitre.
User-reported outcomes on their own platform indicate improvements in scalp condition and hair appearance within four to six weeks of consistent use. These are the manufacturer's figures and user-reported observations, not the outputs of a peer-reviewed clinical trial.
Our Experience at Hair Revive
We began offering E50 Treatment to our clinic in early 2025.
The pattern we see in practice is broadly consistent with what the wider exosome literature reports: where patients have early-to-mid-stage pattern hair loss and follicles are still present, many go on to see improvements in density and hair condition over the course of treatment.
In cases where follicles are no longer active or the hair loss is advanced, the response is limited, which is why we assess every patient before agreeing a course.
This is clinical observation from practice, not a published audit, and we describe it that way. It informs how we approach patient selection and contributes to our confidence in the protocol. It is not a substitute for peer-reviewed evidence, and we are not presenting it as such.
Clinical Observations at The Hair Revive Clinic
We've proudly offered E50-H Treatment for over a year in our Clinic and tracked our own visitors progress over time.
Visit our Results Page to some of the transformations we've achieved:
VISITOR RESULTS →
Is Exosome Hair Restoration Therapy Right For You?
In a world of endless serums, tinctures and procedures it's easy to feel like you're going round in circles.
Exosome Therapy isn't for everybody, and we're upfront about that.
Our 2 Minute Suitability Quiz helps you get a clear picture on whether to proceed with this Treatment or not.
Frequently Asked Questions About the E50-H Exosome
E50-H is sold and marketed by Primacure, with the Exosome being created and manufactured by STEMON Inc., a biotechnology company based in South Korea, using their ENTR® Technology process. It is distributed internationally through various specialist suppliers.
No. E50 is derived from salmon cells, so it is not vegan. It is an animal-derived biological preparation. Specific religious-dietary classifications depend on the framework; you are welcome to raise any questions about this at consultation.
A known salmon or fish allergy is a specific reason to flag treatment at consultation, because the preparation is salmon-derived. Raise it when you book and we will review whether treatment is appropriate for you.
E50 Exosome therapy supports the hair growth cycle rather than permanently changing it. Pattern hair loss is an ongoing biological process, and maintenance sessions or combined treatment strategies are often part of sustaining results over time. We build a review and maintenance plan into the pathway from the start.
PRP uses a concentrated portion of your own blood and is typically injected. E50 is a salmon-derived preparation delivered topically with microneedling. PRP has a larger published evidence base, particularly a 2025 meta-analysis covering 43 randomised controlled trials, whereas E50 specifically has a smaller direct evidence base.
In many cases, yes. A combined approach is often clinically sensible, because different treatments target different parts of the problem. Your consultation will look at any existing medications and plan accordingly.
No. Exosomes are cell-free parcels released by cells, not stem cells themselves. E50 delivers the signalling molecules that exosomes carry, not living cells. That is a different kind of intervention, with a different regulatory classification and different clinical considerations.
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Hair Revive at Dr Aesthetica
Unit 1, 1431–1433 Bristol Road South
Birmingham, West Midlands B31 2SU